高亚丽,马广超,张海波,狄驰

• 1:东北电力大学机械工程学院
• 2:中海石油华鹤煤化有限公司

摘要(Abstract)：

为提高医用AZ91HP镁合金的耐蚀性和生物相容性,采用激光熔凝技术对镁合金进行熔凝处理。结果表明,AZ91HP镁合金熔凝层相组成为α-Mg和β-Mg17Al12,凝固组织为典型的树枝晶。模拟体液中腐蚀速率结果表明,熔凝层的耐蚀性较原始镁合金显著提高。在Hank’s中浸泡21 d后,可清楚看到一些絮状物沉积在熔凝层表面;能谱分析结果表明,絮状物中Ca,P比约为1.33,接近羟基磷灰石中Ca,P比(1.67)。原始镁合金的凝血酶原时间(PT)值为11.025 s,激光熔凝层的PT值为12.025 s,熔凝层具有较好的抗凝血性。细胞毒性实验结果表明,培养1 d后,在原始镁合金周围细胞出现破碎和固缩,极少数贴壁细胞。熔凝层表面则存在许多粘附细胞,熔凝层细胞死亡率较原始镁合金大有降低。

关键词(KeyWords)： 医用镁合金;激光熔凝层;耐蚀性;生物相容性

Abstract:

Keywords:

基金项目(Foundation): 东北电力大学青年学术骨干科研促进计划项目

作者(Author): 高亚丽,马广超,张海波,狄驰

DOI: 10.13289/j.issn.1009-6264.2015.01.029

参考文献(References)：

• [1]彭友霖,周丽丽,周艳红.镁合金作为生物医用植入材料的临床应用[J].中国组织工程研究与临床康复,2011,15(42):7923-7926.PENG You-lin,ZHOU Li-li,ZHOU Yan-hong.Magnesium alloys act as biomedical implant materials[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(42):7923-7926.
• [2]曾荣昌,孔令鸿,陈君,等.医用镁合金表面改性研究进展[J].中国有色金属学报,2011,21(1):35-43.ZENG Rong-chang,KONG Ling-hong,CHEN Jun,et al.Research progress on surface modification of magnesium alloys for medical applications[J].The Chinese Journal of Nonferrous Metals,2011,21(1):35-43.
• [3]李涛,张海龙,何勇,等.生物医用镁合金研究进展[J].功能材料,2013,44(20):2913-2918.LI Tao,ZHAGN Hai-long,HE Yong.Research progress in biomedical magnesium alloy[J].Functional Material,2013,44(20):2913-2918.
• [4]Wang Y M,Guo J W,Shao Z K,et al.A metasilicate-based ceramic coating formed on magnesium alloy by microarc oxidation and its corrosion in simulated bodyuid[J].Surface&Coatings Technology,2013,29:8-14.
• [5]Frank Witte,Frank Feyerabend,Petra Maier,et al.Biodegradable magnesium-hydroxyapatite metalmatrix composites[J].Biomaterials,2007,28:2163-2174.
• [6]Bornapour M,Celikin M,Cerruti M.Magnesium implant alloy with low levels of strontiumand calcium:The third element effect and phase selection improve bio-corrosion resistance and mechanical performance[J].Materials Science and Engineering C,2014,35:267-282.
• [7]张雅静,张丹,习小慧,等.AZ31仿生沉积羟基磷灰石涂层的研究[J].东北大学学报,2011,32(11):1611-1614.ZHANG Ya-jing,ZHANG Dan,XI Xiao-hui,et al.Study on biomimetic hydroxyapatite coating on surface of AZ31 alloy[J].Journal of Northeastern University,2011,32(11):1611-1614.
• [8]Xin yu Yea,Shu Cai,Ying Dou.Bioactive glass-ceramic coating for enhancing the in vitro corrosion resistance of biodegradable Mg alloy[J].Applied Surface Science,2012,259:799-805.
• [9]Yanovskaa A,Kuznetsova V,Stanislavov A.Calcium-phosphate coatings obtained biomimetically on magnesium substrates under low magneticeld[J].Applied Surface Science,2012,258:8577-8584.
• [10]高亚丽,接勐,张海波.医用镁合金激光重熔羟基磷灰石涂层[J].材料热处理学报,2012,33(9):117-121.GAO Ya-li,JIE Meng,ZHANG Hai-bo.Laser remelting hydroxyapatite coating on medical Mg alloy[J].Transactions of Materials and Heat Treatment,2012,33(9):117-121.
• [11]刘其斌.宽带激光熔覆梯度生物陶瓷复合涂层及其生物相容性[D].大连:大连理工大学,2005.
• [12]阅堆宪,王太章,王翰章,等,致密多晶羟基磷灰石微粒人工骨的血液相容性[J].华西口腔医学杂志,1991,9(1):25-27.YUE Dui-xian,WANG Tai-zhang,WANG Han-zhang,et al.Blood compatibility of dense polycrystalline hydroxyapatite artificial bone[J].West China Journal of Stomatology,1991,9(1):25-27.
• [13]Merritte.The binding of metal salts and corrosion products to cells and protein in vitro[J].J Biomed Mater Res,1984,18(9):1005-1011.
• [14]黄晶晶.可降解镁基植入材料的研究[D].沈阳:中国科学院,2008.

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