F-掺杂对镁合金表面含羟基磷灰石复合陶瓷涂层性能的影响Properties of fluorine-doped hydroxyapatite ceramic coatings prepared by micro-arc oxidation on magnesium alloy
周广宏,丁红燕,朱庆灵,张娜,侯化龙,曹维克,庞利群
摘要(Abstract):
通过在电解液中添加适量的氟化铵和羟基磷灰石(HA)颗粒,采用微弧氧化法在AZ31B镁合金表面制备了含有F-和HA的活性陶瓷涂层,研究了F-的加入对涂层的组织形貌、耐蚀性能、亲水性能和血液相容性能的影响。结果表明:电解液中添加F-能有效抑制含HA陶瓷膜层的表面微裂纹的形成,并提高了陶瓷涂层的耐蚀性,腐蚀电位从-1.208 V提高至-0.978 V,腐蚀电流密度降低一个数量级,腐蚀速率减缓了近4倍。此外,F-能提高含HA陶瓷膜层的亲水性能,其静态水的接触角从18.7°降为6.8°,表面血小板粘附量显著减少,呈现出良好的血液相容性。
关键词(KeyWords): 镁合金;微弧氧化;HA涂层;耐蚀性;血液相容性
基金项目(Foundation): 国家自然科学基金(51175212);; 江苏省介入医疗器械研究重点实验室开放基金项目(JR1211)
作者(Author): 周广宏,丁红燕,朱庆灵,张娜,侯化龙,曹维克,庞利群
DOI: 10.13289/j.issn.1009-6264.2014.09.032
参考文献(References):
- [1]Schrechenbach J P,Mark G,Scgkittig F.Characterization of anodic apark-cinverted titanium surfaces for biomedical applications[J].Journal of Materials Science:Materials in Medicine,1999,10:453-457.
- [2]Hing K,Best S,Bonfield W.Hydroxyapatite and fluorapatite coatings for fixation of weight loaded implants[J].Journal of Materials Science:Materials in Medicine,1999,10:135-140.
- [3]Suehanek W,Yoshimura M.Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants[J].Journal of Materials Science,1998,13(1):94-117.
- [4]李得元,宋学毅,韩海玲,等.热喷涂HA复合涂层的组织分析[J].沈阳工业大学学报,2012,34(2):144-148.LI De-yuan,SONG Xue-yi,HAN Hai-ling,et al.Analysis on microstructure of hot sprayed HA composite coating[J].Journal of Shenyang University of Technology,2012,34(2):144-148.
- [5]Groot K D,Geesink R,Klein C P,et al.Plasma sprayed coatings of hydroxylapatite[J].Journal of Biomedical Materials Research,1988,21(12):1375-1381.
- [6]Mondragón-cortez P,Vargas-gutiérrez G.Electrophoretic deposition of hydroxyapatite submicron particles at high voltages[J].Materials Letters,2004,58:1336-1339.
- [7]陈民方,由臣,王玉红,等.溅射羟基磷灰石薄膜与钛合金基体结合强度的研究[J].新技术新工艺,2004,l:35-36.CHEN Min-fang,YOU Chen,WANG Yu-hong,et al.Study on bonding strength between sputtering hydroxyapatie film and tiatnium alloy[J].New Technology&New Process,2004,l:35-36.
- [8]Montenero A,Gnappi G,Ferrari M,et al.Sol-gel derived hydroxyapatite coatings on titanium substrate[J].Materials Science,2000,35(11):2791-2797.
- [9]Cook S D,Thoms K A,Kay J F.Experimental coating defects in hydroxylapatite-coated implants[J].Clinical Orthopaedics and Related Research,1991,265:280-290.
- [10]曲海波,宋晨路,程逵,等.纳米含氟磷灰石涂层及其在模拟溶液中的行为[J].过程工程学报,2002,2(4):370-374.QU Hai-bo,SONG Chen-lu,CHENG Kui,et al.A Preliminary Study on in vitro behaviors of sol-gel derived nano fluorapatite/hydroxyapatite coatings[J].The Chinese Journal of Process Engineering,2002,2(4):370-374.
- [11]Gineste L,Gineste M,Ranz X,et al.Degradation of hydroxyapatite,fluorapatite,and fluorhydroxyapatite coatings of dental implants in dogs[J].Journal of Biomedical Materials Research,1999,48(3):224-225.
- [12]Cheng K,Weng W J,Wang H M,et al.In vitro behavior of osteoblast-like cells:the effect of F-content in fluoridated hydroxyapatite coatings[J].Biomaterials,2005,26(32):6288-6295.
- [13]艾桃桃.含氟羟基磷灰石的性能及涂层制备技术[J].现代技术陶瓷,2009(2):7-11.AI Tao-tao.The performance and preparation processes of fluoridated hydroxyapatite coating[J].Advanced Ceramics,2009(2):7-11.
- [14]Qu H,Wei M.The effect of fluoride contents influoridated hydroxyapatite on osteoblast behavior[J].Acta Biomaterialia,2006,2(1):113-119.
- [15]曾荣昌,孔令鸿,陈君,等.医用镁合金表面改性研究进展[J].中国有色金属学报,2011,21(1),35-43.ZENG Rong-chang,KONG Ling-hong,CHEN Jun,et al.Research progress on surface modification of magnesium alloys for medical applications[J].The Chinese Journal of Nonferrous Metals,2011,21(1),35-43.
- [16]Sun Y,Kong M X,Jiao X H.In-vitro evaluation of Mg-4.0Zn-0.2Ca alloy for biomedical application[J].Transactions of Nonferrous Metals Society ofChina,2011,21(S2):252-257.
- [17]袁广银,章晓波,牛佳林,等.新型可降解生物医用镁合金JDBM的研究进展[J].中国有色金属学报,2011,21(10),2476-2488.YUAN Guang-yin,ZHANG Xiao-bo,NIU Jia-lin,et al.Research progress of new type of degradable biomedical magnesium alloys JDBM[J].The Chinese Journal of Nonferrous Metals,2011,21(10),2476-2488.
- [18]Kubásek J,Vojtěch D.Structural and corrosion characterization of biodegradable Mg-RE(RE=Gd,Y,Nd)alloys[J].Transactions of Nonferrous Metals Society of China,2013,23(5):1215-1225.
- [19]Ye C H,Xi T F,Zheng Y F,et al.In vitro corrosion and biocompatibility of phosphating modified WE43 magnesium alloy[J].Transactions of Nonferrous Metals Society of China,2013,23(4):996-1001.
- [20]曲立杰,李慕勤,张二林,等.超声微弧氧化处理镁合金模拟体液中的耐蚀性[J].材料热处理学报,2013,34(3):130-135.QU Li-jie,LI Mu-qin,ZHANG Er-lin,et al.Corrosion resistance of magnesium alloy coated by ultrasonic-micro arc oxidation in simulated body fluid[J].Transactions of Materials and Heat Treatment,2013,34(3):130-135.
- [21]Hahn B D,Park D S,Choi J J,et al.Aerosol deposition of hydroxyapatite-chitosan composite coatings on biodegradable magnesium alloy[J].Surface&Coatings Technology,2011,205(8-9):3112-3118.
- [22]Tang H,Yu D Z,Luo Y,et al.Preparation and characterization of HA microflowers coating on AZ31 magnesium alloy by micro-arc oxidation and a solution treatment[J].Applied Surface Science,2013,264:816-822.
- [23]Li J N,Song Y,Zhang S X,et al.In vitro responses of human bone marrow stromal cells to a fluoridated hydroxyapatite coated biodegradable Mg-Zn alloy[J].Biomaterials,2010,31(22):5782-5788.
- [24]Meng E C,Guan S K,Wang H X,et al.Effect of electrodeposition modes on surface characteristics and corrosion properties of fluorine-doped hydroxyapatite coatings on Mg-Zn-Ca alloy[J].Applied Surface Science,2011,257(11):4811-4816.
- [25]Li J N,Han P,Ji W P,et al.The in vitro indirect cytotoxicity test and in vivo interface bioactivity evaluation of biodegradable FHA coated Mg-Zn alloys[J].Materials Science and Engineering B,2011,176(20):1785-1788.
- [26]Zhang X P,Zhao Z P,Wu F M,et al.Corrosion and wear resistance of AZ91D magnesium alloy with and without microarc oxidation coating in Hank's solution[J].Journal of Materials Science,2007,42(20):8523-8528.
- [27]Andrade J D.Interfaeial phenomena and biomaterials[J].Medical Instrumentation,1973,7:110-120.
- [28]俞耀庭.生物医用材料[M].天津大学出版社,2000.
- [29]王宏刚,葛淑萍,邹兴政,等.医用高氮无镍奥氏体不锈钢的制备与生物相容性研究[J].功能材料,2012,18(43):1-5.WANG Hong-gang,GE Shu-ping,ZOU Xing-zheng,et al.Evaluation on the blood compatibility and cell compatibility of medical high nitrogen nickelfree stainless steel in vitro[J].Journal of Functional Materials,2012,18(43):1-5.
文章评论(Comment):
|
||||||||||||||||||
|
||||||||||||||||||